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Am I getting enough omega-3 fatty acids from my diet?

Am I getting enough omega-3 fatty acids from my diet?

This is one of the most commonly asked questions about omega-3 fatty acids, and it naturally begs the question "what is enough?" Although the answer is and will continue to be the subject of intense investigation, in 2004 an important paper was published that will help define "enough." Harris and von Schacky proposed a new blood test called "the omega-3 index," and presented a case for why it should be considered as a new risk factor for fatal coronary heart disease.

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Omega-3 fatty acid benefits for different patient populations

Omega-3 fatty acid benefits for different patient populations

Omega-3 fatty acids are notable for their protean physiological effects, including regulation of eicosanoid production, cell membrane physiology, gene expression and translation, and metabolism. Such diversity of action allows omega-3 fatty acids to be investigated as potential therapy in a variety of disease states. In fact, there is active omega-3 research in many disparate medical fields.

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Omega-3 fatty acids and heart disease

Omega-3 fatty acids and heart disease

Though omega-3 fatty acids are being applied to a variety of disease states; arguably, the most prominent and extensively investigated is in the area of cardiovascular illness. Such research began in the early 1970s with the discovery that Northern European Eskimos, whose food intake was limited primarily to omega-3 fatty acid rich fatty animal meats and fish, had substantially lower levels of blood lipids and lower rates of heart disease than their European counterparts, who consumed a less fatty, more "balanced" diet (1). Since then, omega-3 fatty acids have been linked to salutary cardiovascular effects.

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What you need to know about omega-3 fatty acids before recommending them to your patients

Although the putative benefits of omega-3 fatty acids are frequently addressed in the lay press and the medical literature, confusion and misperceptions remain. Before recommending omega-3 fatty acids to patients beyond the dietary sources supported by the Institute of Medicine and Dietary Guidelines for Americans, there are some points that clinicians should be familiar with.

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Will omega-3 fatty acids interact with medications?

While the long chain omega-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are derived from dietary (primarily marine) sources, they are still theoretically capable of interacting with other pharmacologic compounds to alter bioactivity. Click on the link to see what data are available on omega-3 fatty acids and drug interactions.

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Benefits of omega-3 fatty acids in kidney disease patients

Individuals with kidney disease offer a unique group in which to study the potential benefits of marine-derived omega-3 fatty acids, especially given their inadequate dietary intake1 and numerous complications. However, research in this area is still in its early stages.

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